EFFECT OF ISOLATION ON BEHAVIORAL, MODELS INVOLVING SEROTONERGIC 5-HT2 AND 5-HT1A RECEPTORS

1 The effect of 7 days of isolation were observed in mice on behavioural models involving 5-HT2 and 5-HT1A receptors. 2 The sensitivity of 5-HT2 receptors as assessed through L-5-HTP or 5-MeODMT induced head-twitches was reduced. 3 The sensitivity of the 5-HT1A receptors implicated in the 8-OH-DPAT induced feeding was unchanged. 4 The sensitivity of the 5-HT1A receptors involved in the 8-OH-DPAT induced hypothermia was diminished. 5 On the whole, these results show that after 7 days of isolation, the responses to the stimulation of serotonergic receptors is unchanged or diminished according to both the receptor's subtype and the model used.