INHIBITORS OF CYCLIC-AMP PHOSPHODIESTERASE .2. STRUCTURAL VARIATIONS OF N-CYCLOHEXYL-N-METHYL-4-[(1,2,3,5-TETRAHYDRO-2-OXOIMIDAZO[2,1-B]QUINAZOLIN-7-YL)-OXY]BUTYRAMIDE (RS-82856)

被引：35

作者：

VENUTI, MC ^{[1
]}

JONES, GH ^{[1
]}

ALVAREZ, R ^{[1
]}

BRUNO, JJ ^{[1
]}

机构：

[1] SYNTEX RES CORP, INST BIOL SCI, PALO ALTO, CA 94304 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1987年 / 30卷 / 02期

关键词：

D O I：

10.1021/jm00385a012

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：303 / 318

页数：16

共 66 条

[1] EFFECTS OF SEVERAL NEWER CARDIOTONIC DRUGS ON CARDIAC CYCLIC-AMP METABOLISM [J].

AHN, HS ;

EARDLEY, D ;

WATKINS, R ;

PRIOLI, N .

BIOCHEMICAL PHARMACOLOGY, 1986, 35 (07) :1113-1121

[2]

ALVAREZ R, 1986, MOL PHARMACOL, V29, P554

[3] CATALYTIC ACTIVITIES OF SALICYLALDEHYDE DERIVATIVES .3. IMPROVED SYNTHESIS OF 6-NITROSALICYLALDEHYDE [J].

ANDO, M ;

EMOTO, S .

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1973, 46 (09) :2903-2904

[4]

APPLEMAN MM, 1984, ADV CYCLIC NUCLEOTID, V16, pR6

[5] ACETYLATION AND S-ALKYLATION OF ETHYLENE THIOUREA [J].

BAER, JE ;

LOCKWOOD, RG .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1954, 76 (04) :1162-1164

[6] 6-METHYL-1,2,3,5-TETRAHYDROIMIDAZO[2,1-B]QUINAZOLIN-2-ONE, A POTENT INHIBITOR OF ADP-INDUCED PLATELET-AGGREGATION [J].

BEVERUNG, WN ;

PARTYKA, RA .

JOURNAL OF MEDICINAL CHEMISTRY, 1975, 18 (02) :224-225

[7]

BEVERUNG WN, 1976, Patent No. 3932407

[8] CARDIOTONIC AGENTS .1. 4,5-DIHYDRO-6-[4-(1H-IMIDAZOL-1-YL)PHENYL]-3(2H)-PYRIDAZINONES - NOVEL POSITIVE INOTROPIC AGENTS FOR THE TREATMENT OF CONGESTIVE HEART-FAILURE [J].

BRISTOL, JA ;

SIRCAR, I ;

MOOS, WH ;

EVANS, DB ;

WEISHAAR, RE .

JOURNAL OF MEDICINAL CHEMISTRY, 1984, 27 (09) :1099-1101

[9]

BROWN HC, 1979, SYNTHESIS-STUTTGART, P704

[10] SYNTHESEN IN DER IMIDAZOLON-REIHE [J].

BRUNKEN, J ;

BACH, G .

CHEMISCHE BERICHTE-RECUEIL, 1956, 89 (06) :1363-1373

← 1 2 3 4 5 6 7 →