PARTIAL KINETIC RESOLUTION RESULTING FROM A DEUTERIUM-ISOTOPE EFFECT

被引：2

作者：

ANASTASIS, P ^{[1
]}

DUFFIN, R ^{[1
]}

GILMORE, C ^{[1
]}

OVERTON, K ^{[1
]}

机构：

[1] UNIV GLASGOW,DEPT CHEM,GLASGOW G12 8QQ,SCOTLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1991年 / 12期

关键词：

D O I：

10.1039/c39910000801

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The 'racemate' 1A/1B cyclises on heating to the enol 5 via an 'ene' reaction; at two-thirds completion, the recovered enone 1A/1B has [alpha]D -62-degrees (1B has [alpha]D -132-degrees) kinetic 'resolution' results from a deuterium isotope effect for the cyclisation (k(H)/k(D) ca. 1.8); the absolute stereochemistry of compound 6a is determined by X-ray analysis.

引用

页码：801 / 802

页数：2

共 9 条

[1]

Eisenbaumer R. L., 1979, J ORG CHEM, V44, P600

[2]

FOHLISCH B, 1973, LIEBIGS ANN CHEM, P1839

[3] MITHRIL - AN INTEGRATED DIRECT-METHODS COMPUTER-PROGRAM [J].