(HX)N REPEATS - A PH-CONTROLLED PROTEIN PROTEIN-INTERACTION MOTIF OF EUKARYOTIC TRANSCRIPTION FACTORS

被引：30

作者：

JANKNECHT, R

SANDER, C

PONGS, O

机构：

[1] EUROPEAN MOLEC BIOL LAB,MEYERHOFSTR 1,W-6900 HEIDELBERG,GERMANY

[2] HANOVER MED SCH,INST MOLEK BIOL,W-3000 HANNOVER 61,GERMANY

[3] RUHR UNIV BOCHUM,LEHRSTUHL BIOCHEM,W-4630 BOCHUM,GERMANY

来源：

FEBS LETTERS | 1991年 / 295卷 / 1-3期

关键词：

GENE REGULATION; TRANSCRIPTION FACTOR; DIMERIZATION; ZN-BINDING; SEQUENCE ANALYSIS;

D O I：

10.1016/0014-5793(91)81369-J

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A characteristic sequence repeat of type His-X, repeated several times in a row, is present in several eukaryotic transcription factors, e.g. HPHAHPHP in paired protein. Detailed molecular modelling and database searches lead to the suggestion that (HX)n repeats can mediate interaction between transcription factors in a pH-controlled fashion.

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页码：1 / 2

页数：2

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