NALOXONE-INDUCED ANALGESIA IN DIABETIC MICE

被引：26

作者：

KAMEI, J

KAWASHIMA, N

KASUYA, Y

机构：

[1] Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa-ku, Tokyo, 142, 4-41

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 210卷 / 03期

关键词：

DIABETES; NALOXONE; PARADOXICAL ANALGESIA; NALTRINDOLE; (MOUSE);

D O I：

10.1016/0014-2999(92)90424-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We evaluated the effects of s.c. administration of naloxone in mice with streptozotocin-induced diabetes, compared to those in age-matched naive mice. Naloxone injected s.c. produced a dose-related increase in tail-flick latency in diabetic mice but not in naive mice. Naloxone-induced analgesia in diabetic mice was significantly reduced by pretreatment with naltrindole, a selective antagonist of delta-opioid receptors. These results indicate that naloxone-induced 'paradoxical' analgesia in diabetic mice may be mediated by delta-opioid receptors.

引用

页码：339 / 341

页数：3

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