A BIORESORBABLE URETHRAL STENT - AN EXPERIMENTAL-STUDY

被引：92

作者：

KEMPPAINEN, E

TALJA, M

RIIHELA, M

POHJONEN, T

TORMALA, P

ALFTHAN, O

机构：

[1] KUOPIO UNIV HOSP,SURG CLIN,HELSINKI,FINLAND

[2] JORVI HOSP,DEPT PATHOL,HELSINKI,FINLAND

[3] TAMPERE UNIV TECHNOL,INST PLAST TECHNOL,SF-33101 TAMPERE 10,FINLAND

来源：

UROLOGICAL RESEARCH | 1993年 / 21卷 / 03期

关键词：

BIODEGRADABLE MATERIAL; EXPERIMENTAL STUDY; URETHRAL STENT; URETHRAL STRICTURE;

D O I：

10.1007/BF00590042

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The aim of the present study was to examine the suitability of biodegradable polymers as materials for a urethral stent. A new urethral stent made of biodegradable self-reinforced poly-L-lactide (SR-PLLA) was implanted in 16 male rabbits after urethrotomy. Seven stents of stainless steel served as controls. The dimensions of the two types of stents were identical: length 15 mm, diameter 8.2 mm. The mechanical construction was a helical spiral. The SR-PLLA spiral was sustained with three microspirals, and the whole device was coated with DL-lactide to achieve an active initial tissue reaction and better tissue penetration. The SR-PLLA stent showed more favourable implantation properties than the steel one. Within 6 months all PLLA stents had implanted, and the tissue reaction around the stent material was minimal. The helical spiral of stainless steel induced a remarkable inflammatory reaction due to poor implantation properties. We suggest that biodegradable SR-PLLA is a promising material for a urethral stent to prevent re-stenosis of urethral strictures.

引用

页码：235 / 238

页数：4

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