ASSOCIATION OF ERYTHROID TRANSCRIPTION FACTORS - COMPLEXES INVOLVING THE LIM PROTEIN RBTN2 AND THE ZINC-FINGER PROTEIN GATA1

被引：172

作者：

OSADA, H ^{[1
]}

GRUTZ, G ^{[1
]}

AXELSON, H ^{[1
]}

FORSTER, A ^{[1
]}

RABBITTS, TH ^{[1
]}

机构：

[1] MRC,MOLEC BIOL LAB,CAMBRIDGE CB2 2QH,ENGLAND

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1995年 / 92卷 / 21期

关键词：

D O I：

10.1073/pnas.92.21.9585

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The RBTN2 LIM-domain protein, originally identified as an oncogenic protein in human T-cell leukemia, is essential for erythropoiesis. A possible role for RBTN2 in transcription during erythropoiesis has been investigated. Direct interaction of the RBTN2 protein was observed in vivo and in vitro with the GATA1 or -2 zinc-finger transcription factors, as well as with the basic helix-loop-helix protein TAL1. By using mammalian two-hybrid analysis, complexes involving RBTN2, TAL1, and GATA1, together with E47, the basic helix-loop-helix heterodimerization partner of TAL1, could be demonstrated, Thus, a molecular link exists between three proteins crucial for erythropoiesis, and the data suggest that variations in amounts of complexes involving RBTN2, TAL1, and GATA1 could be important for erythroid differentiation.

引用

页码：9585 / 9589

页数：5

共 38 条

[1] CYSTEINE-RICH LIM DOMAINS OF LIM-HOMEODOMAIN AND LIM-ONLY PROTEINS CONTAIN ZINC BUT NOT IRON [J].