Breast Cancer Biology: The Multifaceted Roles of Mesenchymal StemCells

被引：17

作者：

Patel, Shyam A. ^{[1
,2
]}

Heinrich, Andrew C. ^{[2
]}

Reddy, Bobby Y. ^{[2
]}

Srinivas, Balaji ^{[2
]}

Heidaran, Nicole ^{[2
]}

Rameshwar, Pranela ^{[2
]}

机构：

[1] Univ Med & Dent New Jersey, Grad Sch Biomed Sci, Newark, NJ 07103 USA

[2] Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Med, Div Hematol & Oncol, Newark, NJ 07103 USA

来源：

JOURNAL OF ONCOLOGY | 2008年 / 2008卷

关键词：

D O I：

10.1155/2008/425895

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent upsurge in the interest of breast cancer metastasis is partly attributed to the discovery of novel, yet unclear, mechanisms of breast cancer interaction with sites of distant metastasis such as the bone marrow microenvironment. In this review, we discuss the significance of the interactions between breast cancer cells and cells of the bonemarrow. This is a subject of intense research studies aim to provide new methods of treatments and perhaps the identification of new drug targets. This review also discusses the role of inflammation and the bimodal function of the transforming growth factor-beta signaling pathway in the process of tumorigenesis. We bring attention to future prospects in breast cancer research, including the role of microRNAs in cancer quiescence in the bone marrow and the application of microRNAs to basic science discoveries in oncology. Finally, we discuss the cancer stem cell hypothesis, which is not a new idea, but has resurged with investigative questions. Copyright (C) 2008 Shyam A. Patel et al.

引用

页数：7

共 41 条

[1] Tumor environment dictates medulloblastoma cancer stem cell expression and invasive phenotype [J].

Annabi, Borhane ;

Rojas-Sutterlin, Shanti ;

Laflamme, Carl ;

Lachambre, Marie-Paule ;

Rolland, Yanneve ;

Sartelet, Herve ;

Beliveau, Richard .

MOLECULAR CANCER RESEARCH, 2008, 6 (06) :907-916

[2] Hematopoietic growth factor inducible neurokinin-1 type: a transmembrane protein that is similar to neurokinin 1 interacts with substance P [J].

Bandari, PS ;

Qian, J ;

Yehia, G ;

Joshi, DD ;

Maloof, PB ;

Potian, J ;

Oh, HS ;

Gascon, P ;

Harrison, JS ;

Rameshwar, P .

REGULATORY PEPTIDES, 2003, 111 (1-3) :169-178

[3] Temozolomide preferentially depletes cancer stem cells in glioblastoma [J].

Beier, Dagmar ;

Roehrl, Stefanie ;

Pillai, Deepu R. ;

Schwarz, Stefanie ;

Kunz-Schughart, Leoni A. ;

Leukel, Petra ;

Proescholdt, Martin ;

Brawanski, Alexander ;

Bogdahn, Ulrich ;

Trampe-Kieslich, Ariane ;

Giebel, Bernd ;

Wischhusen, Joerg ;

Reifenberger, Guido ;

Hau, Peter ;

Beier, Christoph P. .

CANCER RESEARCH, 2008, 68 (14) :5706-5715

[4]

Brenner MK, 2008, ADV EXP MED BIOL, V610, P88, DOI 10.1007/978-0-387-73898-7_7

[5] Positive correlations of Oct-4 and Nanog in oral cancer stem-like cells and high-grade oral squamous cell carcinoma [J].

Chiou, Shih-Hwa ;

Yu, Cheng-Chia ;

Huang, Chi-Yang ;

Lin, Shu-Chun ;

Liu, Chung-Ji ;

Tsai, Tung-Hu ;

Chou, Shiu-Huey ;

Chien, Chian-Shiu ;

Ku, Hung-Hai ;

Lo, Jeng-Fan .

CLINICAL CANCER RESEARCH, 2008, 14 (13) :4085-4095

[6] Nuclear factor-κB accounts for the repressor effects of high strornal cell-derived factor-1α levels on Tac1 expression in nontumorigenic breast cells [J].

Corcoran, Kelly E. ;

Rameshwar, Pranela .

MOLECULAR CANCER RESEARCH, 2007, 5 (04) :373-381

[7] Mesenchymal Stem Cells in Early Entry of Breast Cancer into Bone Marrow [J].

Corcoran, Kelly E. ;

Trzaska, Katarzyna A. ;

Fernandes, Helen ;

Bryan, Margarette ;

Taborga, Marcelo ;

Srinivas, Venkatesh ;

Packman, Kathryn ;

Patel, Prem S. ;

Rameshwar, Pranela .

PLOS ONE, 2008, 3 (06)

[8]

Douville J., STEM CELLS IN PRESS

[9] T regulatory cells contribute to the attenuated primary CD8+ and CD4+ T cell responses to herpes simplex virus type 2 in neonatal mice [J].

Fernandez, Marian A. ;

Puttur, Franz K. ;

Wang, Yuan M. ;

Howden, Wade ;

Alexander, Stephen I. ;

Jones, Cheryl A. .

JOURNAL OF IMMUNOLOGY, 2008, 180 (03) :1556-1564

[10] MicroRNAs regulate synthesis of the neurotransmitter substance P in human mesenchymal stem cell-derived neuronal cells [J].

Greco, Steven J. ;

Rameshwar, Pranela .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (39) :15484-15489

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