Salivary biomarkers in psychobiological medicine

被引：26

作者：

Chiappelli, Francesco ^{[1
]}

Iribarren, Francisco Javier ^{[2
]}

Prolo, Paolo ^{[1
]}

机构：

[1] UCLA, Sch Dent, CHS 63-090, Los Angeles, CA 90095 USA

[2] UCLA, Sch Med, Los Angeles, CA 90095 USA

来源：

BIOINFORMATION | 2006年 / 1卷 / 08期

关键词：

saliva; biomarker; physiology; psychobiology; diagnosis;

D O I：

10.6026/97320630001331

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The value of salivary biomarkers for diagnostic and prognostic assessments has become increasingly well established in medicine, pharmacology, and dentistry. Certain salivary components mirror the neuro-endocrine status of the organism. Other saliva products are protein in nature, and can serve to reflect immune surveillance processes. The autonomic nervous system regulates the process of salivation, and the concentration of yet other salivary components, such as alpha-amylase, which provide a reliable outcome measure of the sympathetic response. Here, we discuss molecular technologies that have permitted giant steps in the utilization of salivary samples and micro-fluidics for the benefit of diagnostic medicine and dentistry, and their putative role in springing forward research in psychobiology.

引用

页码：331 / 334

页数：4

共 12 条

[1]

[Anonymous], 2006, PSYCHOSOM MED

[2] Salivary alpha-amylase as a measure of endogenous adrenergic activity [J].

Chatterton, RT ;

Vogelsong, KM ;

Lu, YC ;

Ellman, AB ;

Hudgens, GA .

CLINICAL PHYSIOLOGY, 1996, 16 (04) :433-448

[3]

Chiappelli F, 2006, NEUROAIDS, P121

[4] Asymmetry between salivary cortisol and α-amylase reactivity to stress:: Relation to aggressive behavior in adolescents [J].

Gordis, Elana B. ;

Granger, Douglas A. ;

Susman, Elizabeth J. ;

Trickett, Penelope K. .

PSYCHONEUROENDOCRINOLOGY, 2006, 31 (08) :976-987

[5] Daily goal pursuits predict cortisol secretion and mood states in employed parents with preschool children [J].

Hoppmann, Christiane A. ;

Klumb, Petra L. .

PSYCHOSOMATIC MEDICINE, 2006, 68 (06) :887-894

[6] Human saliva proteome and transcriptome [J].

Hu, S. ;

Li, Y. ;

Wang, J. ;

Xie, Y. ;

Tjon, K. ;

Wolinsky, L. ;

Loo, R. R. O. ;

Loo, J. A. ;

Wong, D. T. .

JOURNAL OF DENTAL RESEARCH, 2006, 85 (12) :1129-1133

[7] Optimism, positive affectivity, and salivary cortisol [J].

Lai, JCL ;

Evans, PD ;

Ng, SH ;

Chong, AML ;

Siu, OT ;

Chan, CLW ;

Ho, SMY ;

Ho, RTH ;

Chan, P ;

Chan, CC .

BRITISH JOURNAL OF HEALTH PSYCHOLOGY, 2005, 10 :467-484

[8] RNA profiling of cell-free saliva using microarray technology [J].

Li, Y ;

Zhou, X ;

John, MARS ;

Wong, DTW .

JOURNAL OF DENTAL RESEARCH, 2004, 83 (03) :199-203

[9]

Li Y., 2004, CLIN CANCER RES, V10, P8130

[10] Stress-induced changes in human salivary alpha-amylase activity-associations with adrenergic activity [J].

Nater, UM ;

La Marca, R ;

Florin, L ;

Moses, A ;

Langhans, W ;

Koller, MM ;

Ehlert, U .

PSYCHONEUROENDOCRINOLOGY, 2006, 31 (01) :49-58

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