SYNTHESIS OF BETA-ADRENERGIC BLOCKING-AGENT TIMOLOL FROM OPTICALLY-ACTIVE PRECURSORS

被引：94

作者：

WEINSTOCK, LM ^{[1
]}

MULVEY, DM ^{[1
]}

TULL, R ^{[1
]}

机构：

[1] MERCK SHARP & DOHME, RES LABS, RAHWAY, NJ 07065 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1976年 / 41卷 / 19期

关键词：

D O I：

10.1021/jo00881a011

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of the .beta.-adrenergic blocking agent, timolol, from optically active precursors is described and confirmation of its absolute configuration is presented.

引用

页码：3121 / 3124

页数：4

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