MAPPING AND DIRECT VISUALIZATION OF A REGION-SPECIFIC VIRAL-DNA INTEGRATION SITE ON CHROMOSOME-19Q13-QTER

被引：263

作者：

KOTIN, RM

MENNINGER, JC

WARD, DC

BERNS, KI

机构：

[1] CORNELL UNIV,MED CTR,COLL MED,HEARST MICROBIOL RES CTR,DEPT MICROBIOL,NEW YORK,NY 10021

[2] YALE UNIV,SCH MED,DEPT HUMAN GENET MOLEC BIOPHYS & BIOCHEM,NEW HAVEN,CT 06510

来源：

GENOMICS | 1991年 / 10卷 / 03期

关键词：

POLYMERASE CHAIN-REACTION; INSITU HYBRIDIZATION; HUMAN-CHROMOSOMES; VIRUS; CELLS; SEQUENCES; MINISATELLITE; RECOMBINATION; ALU;

D O I：

10.1016/0888-7543(91)90470-Y

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A human parvovirus, adeno-associated virus (AAV), is unique among eukaryotic DNA viruses in its ability to integrate site specifically into a defined region of human chromosome 19. In this study we used in situ hybridization to visualize directly the site of AAV DNA integration in latently infected human cell lines and normal human cells. © 1991.

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页码：831 / 834

页数：4

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