PREVALENCE OF ANTIBODY AGAINST NON-A, NON-B HEPATITIS-VIRUS IN JAPANESE PATIENTS WITH HEPATOCELLULAR-CARCINOMA

被引：89

作者：

OHKOSHI, S

KOJIMA, H

TAWARAYA, H

MIYAJIMA, T

KAMIMURA, T

ASAKURA, H

SATOH, A

HIROSE, S

HIJIKATA, M

KATO, N

SHIMOTOHNO, K

机构：

[1] NATL CANC CTR,DIV VIROL,5-1-1 TSUKJI,CHUO KU,TOKYO 104,JAPAN

[2] NIIGATA CITY HOSP,NIIGATA 950,JAPAN

[3] NAGAOKA RED CROSS HOSP,NAGAOKA 940,JAPAN

[4] NIIGATA UNIV,SCH MED,DEPT INTERNAL MED 3,NIIGATA 95021,JAPAN

来源：

JAPANESE JOURNAL OF CANCER RESEARCH | 1990年 / 81卷 / 6-7期

关键词：

Antibody; Hepatitis C virus; Hepatocellular carcinoma; Non‐A; non‐B hepatitis virus;

D O I：

10.1111/j.1349-7006.1990.tb02605.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Antibodies against a possible causative agent of non‐A, non‐B hepatitis, hepatitis C virus (HCV), in Japanese patients with hepatocellular carcinoma were analyzed using the enzyme‐linked immunosorbent assay (ELISA) system from Ortho Diagnostic Systems, Japan. Fifty of 58 cases of hepatitis B virus surface antigen (HBsAg)‐negative hepatocellular carcinoma were positive for the antibody (86%) and 8 of 42 cases of HBsAg‐positive hepatocellular carcinoma were positive (19%). Among patients with HBsAg‐negative hepatocellular carcinoma, the prevalence of the antibody was greater among those who had received a blood transfusion (97%) than among those with no history of transfusion (70%). Only 3 of 54 patients with cancers other than hepatocellular carcinoma were found to be antibody‐positive (5.6%) and all three patients had a history of blood transfusion. These results show a close relationship between the presence of anti‐HCV antibody and HBsAg‐negative hepatocellular carcinoma in Japan. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：550 / 553

页数：4

共 21 条

[1]

BEASLEY RP, 1981, LANCET, V2, P1129

[2]

BRUIX J, 1989, LANCET, V2, P1004

[3]

CCOLOMBO M, 1989, LANCET, V2, P1006

[4] ISOLATION OF A CDNA CLONE DERIVED FROM A BLOOD-BORNE NON-A, NON-B VIRAL-HEPATITIS GENOME [J].

CHOO, QL ;

KUO, G ;

WEINER, AJ ;

OVERBY, LR ;

BRADLEY, DW ;

HOUGHTON, M .

SCIENCE, 1989, 244 (4902) :359-362

[5]

DIENSTAG JL, 1983, GASTROENTEROLOGY, V85, P439

[6]

ESTEBAN JI, 1989, LANCET, V2, P294

[7] JAPANESE ISOLATES OF THE NON-A, NON-B HEPATITIS VIRAL GENOME SHOW SEQUENCE VARIATIONS FROM THE ORIGINAL ISOLATE IN THE USA [J].

KATO, N ;

OHKOSHI, S ;

SHIMOTOHNO, K .

PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES, 1989, 65 (09) :219-223

[8]

KIYOSAWA K, 1984, AM J GASTROENTEROL, V79, P777

[9]

KIYOSAWA K, 1989, IGAKU TO YAKUGAKU, V22, P607

[10]

KUHNL P, 1989, LANCET, V2, P324

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