GENOTOXIC EFFECTS OF LINEAR ALKYL BENZENE SULFONATE, SODIUM PENTACHLOROPHENATE AND DICHROMATE ON TETRAHYMENA-PYRIFORMIS

被引：6

作者：

WU, YP ^{[1
]}

SHEN, YF ^{[1
]}

机构：

[1] ACAD SINICA,INST HYDROBIOL,WUHAN 430072,PEOPLES R CHINA

来源：

JOURNAL OF PROTOZOOLOGY | 1992年 / 39卷 / 04期

关键词：

DNA; MACRONUCLEAR DNA EXTRUSION BODIES; MICRONUCLEUS; MICROSPECTROPHOTOMETRY;

D O I：

10.1111/j.1550-7408.1992.tb04831.x

中图分类号：

Q95 [动物学];

学科分类号：

071002 ;

摘要：

DNA in macro- and micronuclei of Tetrahymena pyriformis treated with linear alkyl benzene sulfonate (LAS) and sodium pentachlorophenate (PCP-Na) were determined by microspectrophotometry. The effects on rate of formation of macronuclear DNA extrusion bodies were also studied. We found DNA content of micronuclei in 0.14 ppm LAS and 0.9 ppb PCP-Na was lower than in that of the control, and LAS was able to increase the formation rate of macronuclear DNA extrusion bodies (the formation rate was 54% in 11.3 ppm LAS and 25.6% in 16.7 ppm dichromate). We concluded that 0.14 ppm LAS (below the maximum acceptable toxicant concentration) was genotoxic, whereas 0.014 ppm LAS was not. Dichromate 0.05 ppm and 0.9 ppb PCP-Na, equal to and below the maximum acceptable toxicant concentration, respectively, were potentially genetoxic.

引用

页码：454 / 456

页数：3

共 12 条

[1] REPLICATION AND FUNCTIONS OF MACRONUCLEAR DNA IN SYNCHRONOUSLY GROWING POPULATIONS OF TETRAHYMENA PYRIFORMIS [J].