SOLUBILIZATION OF GLIBENCLAMIDE WITH BETA-CYCLODEXTRIN AND ITS DERIVATIVES

Glibenclamide, a widely used potent hypoglycaemic agent was solubilized using beta -Cyclodextrin and beta -Cyclodextrin derivatives. Complexes were prepared by kneading method in a molar ratio of 1:1 of the drug and the cyclodextrins respectively. The Glibenclamide beta-Cyclocextrin complex was characterized and evaluated by I.R. studies, Differential Scanning Calorimetry & X-ray diffractometry. The in-vitro dissolution rates of drug from inclusion complexes of beta - Cyclodextrins and its derivatives were compared. A significant improvement in dissolution rates of Glibenclamide was observed with inclusion complexes of all the Cyclodextrins. However, the solubilizing effect was more in case of beta-Cyclodextrin derivatives.