EGG LIGATION ALTERS THE BCD PROTEIN GRADIENT AND SEGMENTATION GENE-EXPRESSION IN EMBRYOS OF DROSOPHILA

被引:11
作者
BORING, L
WEIR, M
SCHUBIGER, G
机构
[1] UNIV WASHINGTON,DEPT ZOOL,NJ-15,SEATTLE,WA 98195
[2] WESLEYAN UNIV,DEPT BIOL,MIDDLETOWN,CT 06457
关键词
BICOID; EGG LIGATION; GAP GENE; PATTERN FORMATION;
D O I
10.1016/0925-4773(93)90102-4
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
A concentration gradient of the anterior morphogen Bicoid (Bcd) plays a key role in the specification of cell fates in the early Drosophila embryo. We found that introduction of a membrane barrier across the embryo results in increased levels of Bcd protein on the anterior side of the barrier and decreased levels on the posterior side, consistent with a blockage in the postulated anterior-to-posterior translocation of Bcd protein. The expression patterns of downstream segmentation genes were in large part consistent with their regulation by the Bcd morphogen. However, some aspects of the patterns did nol correlate with the altered Bcd distribution, suggesting that other morphogens also regulate the anteroposterior pattern. Our results suggest that axial translocation of morphogens is critical for establishing a well-proportioned body plan.
引用
收藏
页码:97 / 111
页数:15
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