LOW-DOSES OF PENTAGASTRIN STIMULATE GASTRIC LIPASE SECRETION IN MAN

被引：9

作者：

WOJDEMANN, M

NORREGAARD, P

STERNBY, B

WORNING, H

OLSEN, O

机构：

[1] UNIV COPENHAGEN,GLOSTRUP HOSP,DEPT MED F,COPENHAGEN,DENMARK

[2] UNIV LUND HOSP,DEPT MED,CTR EXPTL RES,S-22185 LUND,SWEDEN

来源：

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY | 1995年 / 30卷 / 07期

关键词：

HUMAN GASTRIC LIPASE; PENTAGASTRIN;

D O I：

10.3109/00365529509096304

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background: Gastric lipase is an important enzyme for dietary triglyceride digestion in normal subjects. Its regulation is unknown, as is the relation between the quantity and activity of the enzyme. Methods: In a dose-response study we investigated the effect of low doses of pentagastrin (less than 1000 ng/kg/h) on the output of gastric lipase measured by a kinetic assay and an enzyme-linked immunosorbent assay (ELISA). Results: In five healthy volunteers stepwise intravenous pentagastrin infusions of 0, 50, 100, 500, and 1000 ng/kg/h resulted in a stepwise increase in the lipase output, as measured with ELISA. However, the lipolytic activity, measured with a kinetic assay, decreased as the pH of the gastric contents decreased. Conclusion: We conclude that secretion of the gastric lipase is stimulated by pentagastrin, but the simultaneous secretion of acid counteracts the lipolytic activity of the enzyme when food is not present.

引用

页码：631 / 634

页数：4

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