MODULATION OF COMEDONAL LEVELS OF INTERLEUKIN-1 IN ACNE PATIENTS TREATED WITH TETRACYCLINES

被引:24
作者
EADY, EA [1 ]
INGHAM, E [1 ]
WALTERS, CE [1 ]
COVE, JH [1 ]
CUNLIFFE, WJ [1 ]
机构
[1] GEN INFIRM, LEEDS FDN DERMATOL RES, LEEDS LS1 3EX, W YORKSHIRE, ENGLAND
关键词
D O I
10.1111/1523-1747.ep12360123
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
To understand the basis for the anti-inflammatory activity 0 tetracyclines in acne, we compared the cytokine profiles [interleukin 1 (IL-1) alpha and beta, tumor necrosis factor (TNF) alpha, and IL-6] and bacterial flora of 66 open comedones removed from eleven patients before and after at least 8 weeks treatment with either tetracycline or minocycline. Pre-treatment, the only cytokine regularly recovered from comedones was bioactive IL-1alpha-like material. The mean concentration of IL-1alpha-like bioactivity/mg comedonal material rose from 272.0 +/- 88.6 pg to 844.3 +/- 196.7 pg following treatment (p < 0.05, Wilcoxon matched pairs). All six minocycline-treated patients showed an increase in bioactive IL-1alpha-like material compared with three of five tetracycline-treated patients. The incidence (p < 0.001, chi2) and concentration (p < 0.05, Wilcoxon) of immunochemical IL-beta were also raised post-treatment, although significantly more patients assigned to minocycline therapy had detectable levels of this cytokine before therapy was initiated. However, the mean concentration of IL-1beta/mg comedonal material post-treatment was similar in both groups (72.5 +/- 23.3 pg for tetracycline-treated compared with 78.6 +/- 41.9 pg for minocycline-treated patients). The other cytokines were either absent (IL-6) or present in < 10% of comedones (TNFalpha) before and after therapy. Following treatment, only three of 11 patients showed a decrease of greater-than-or-equal-to 1 log10 in propionibacterial numbers/mg comedonal material, whereas six patients showed an increase of > 0.5 log10 in numbers of staphylococci. In eight patients, the increase or decrease in staphylococcal numbers correlated with the change in concentration of IL-1alpha-like bioactivity. This is the first study to show an effect of antibiotic therapy on cytokine levels in vivo. Increased levels of IL-1 in comedones destined to become inflamed may enhance resolution and promote repair of the damaged follicular epithelium. Hence, these results provide further evidence of the augmentation of immune responses by tetracyclines and support the hypothesis that epidermal IL-1 plays a physiologic role in wound healing.
引用
收藏
页码:86 / 91
页数:6
相关论文
共 32 条
[1]   DIFFERENTIAL MODULATION OF CYTOKINE PRODUCTION BY MACROLIDES - INTERLEUKIN-6 PRODUCTION IS INCREASED BY SPIRAMYCIN AND ERYTHROMYCIN [J].
BAILLY, S ;
POCIDALO, JJ ;
FAY, M ;
GOUGEROTPOCIDALO, MA .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1991, 35 (10) :2016-2019
[2]   KERATINOCYTES AS INITIATORS OF INFLAMMATION [J].
BARKER, JNWN ;
MITRA, RS ;
GRIFFITHS, CEM ;
DIXIT, VM ;
NICKOLOFF, BJ .
LANCET, 1991, 337 (8735) :211-214
[3]   THE ASSESSMENT OF ACNE-VULGARIS - THE LEEDS TECHNIQUE [J].
BURKE, BM ;
CUNLIFFE, WJ .
BRITISH JOURNAL OF DERMATOLOGY, 1984, 111 (01) :83-92
[4]   POTENT INFLAMMATORY PROPERTIES IN HUMAN SKIN OF INTERLEUKIN-1 ALPHA-LIKE MATERIAL ISOLATED FROM NORMAL SKIN [J].
CAMP, R ;
FINCHAM, N ;
ROSS, J ;
BIRD, C ;
GEARING, A .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1990, 94 (06) :735-741
[5]  
CHU E, 1984, J IMMUNOL, V132, P1311
[6]  
COOPER KD, 1990, J IMMUNOL, V144, P4593
[7]  
CUNLIFFE WJ, 1989, ACNE, P11
[8]   COMPLEMENT C-3 AND IMMUNOGLOBULIN IN INFLAMMATORY ACNE-VULGARIS [J].
DAHL, MGC ;
MCGIBBON, DH .
BRITISH JOURNAL OF DERMATOLOGY, 1979, 101 (06) :633-640
[9]   SUPERIOR ANTIBACTERIAL ACTION AND REDUCED INCIDENCE OF BACTERIAL-RESISTANCE IN MINOCYCLINE COMPARED TO TETRACYCLINE-TREATED ACNE PATIENTS [J].
EADY, EA ;
COVE, JH ;
HOLLAND, KT ;
CUNLIFFE, WJ .
BRITISH JOURNAL OF DERMATOLOGY, 1990, 122 (02) :233-244
[10]   THE USE OF ANTIBIOTICS IN ACNE THERAPY - ORAL OR TOPICAL ADMINISTRATION [J].
EADY, EA ;
HOLLAND, KT ;
CUNLIFFE, WJ .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1982, 10 (02) :89-115