ANTIBODIES TO CEREBELLAR SOLUBLE LECTIN CSL IN MULTIPLE-SCLEROSIS

被引：21

作者：

ZANETTA, JP ^{[1
]}

WARTER, JM ^{[1
]}

KUCHLER, S ^{[1
]}

MARSCHAL, P ^{[1
]}

RUMBACH, L ^{[1
]}

LEHMANN, S ^{[1
]}

TRANCHANT, C ^{[1
]}

REEBER, A ^{[1
]}

VINCENDON, G ^{[1
]}

机构：

[1] UNIV STRASBOURG 1,SERV NEUROL 2,F-67070 STRASBOURG,FRANCE

来源：

LANCET | 1990年 / 335卷 / 8704期

关键词：

D O I：

10.1016/0140-6736(90)93027-M

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cerebrospinal fluid samples from 239 patients with various neurological disorders were tested for the presence of autoantibodies to an endogenous mannose-binding protein, the cerebellar soluble lectin CSL, by means of an immunoblotting test with rat CSL as antigen. 47 of 51 patients with multiple sclerosis were positive for anti-CSL compared with 30 of 188 patients with other neurological disorders. 14 of the 30 false-positive patients were over 60 years old, an age group not typical of multiple sclerosis patients. The specificity of the test for multiple sclerosis was 85% and the sensitivity 93·5%. The possibility that CSL is an important immunological target in multiple sclerosis allows new insights into the possible causes and development of this disorder. © 1990.

引用

页码：1482 / 1484

页数：3

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