MALARIA VACCINES - CURRENT STATUS

被引：5

作者：

CORRADIN, G

ENGERS, H

TRIGG, PI

机构：

[1] WHO, SPECIAL PROGRAMME RES & TRAINING TROP DIS, WORLD BANK, UNDP, CH-1211 GENEVA 27, SWITZERLAND

[2] WHO, DIV CONTROL TROP DIS, MALARIA UNIT, CH-1211 GENEVA 27, SWITZERLAND

来源：

CLINICAL IMMUNOTHERAPEUTICS | 1994年 / 1卷 / 03期

关键词：

D O I：

10.1007/BF03258505

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In recent years, many malaria parasite genes and proteins specific for different stages of the plasmodium life cycle have been identified, sequenced, expressed and characterised in terms of their biological and immunological properties. Antibodies to certain full length proteins or fragments thereof have been shown to inhibit parasite growth, either in vitro or in vivo. Thus, these antigens hold considerable promise for testing as candidate vaccines. Several of them are at an advanced stage of development, with phase I/II human clinical trials underway or expected for the near future.

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页码：191 / 198

页数：8

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