ACTIN-BINDING PROTEIN (ABP-280) FILAMIN GENE (FLN) MAPS TELOMERIC TO THE COLOR-VISION LOCUS (R/GCP) AND CENTROMERIC TO G6PD IN XQ28

被引：37

作者：

GORLIN, JB

HENSKE, E

WARREN, ST

KUNST, CB

DURSO, M

PALMIERI, G

HARTWIG, JH

BRUNS, G

KWIATKOWSKI, DJ

机构：

[1] BRIGHAM & WOMENS HOSP,DEPT MED,DIV EXPTL MED,BOSTON,MA 02115

[2] BRIGHAM & WOMENS HOSP,DEPT MED,DIV HEMATOL ONCOL,BOSTON,MA 02115

[3] CHILDRENS HOSP MED CTR,DIV GENET,BOSTON,MA 02115

[4] HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DIV PEDIAT ONCOL,BOSTON,MA 02115

[5] EMORY UNIV,SCH MED,DEPT PEDIAT,ATLANTA,GA 30322

[6] EMORY UNIV,SCH MED,DEPT BIOCHEM,ATLANTA,GA 30322

[7] INT INST GENET & BIOPHYS,NAPLES,ITALY

[8] EMORY UNIV,SCH MED,HOWARD HUGHES MED INST,ATLANTA,GA 30322

来源：

GENOMICS | 1993年 / 17卷 / 02期

关键词：

D O I：

10.1006/geno.1993.1354

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Actin-binding protein-280 (ABP-280) is a dimeric actin filament crosslinking protein that promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. We have mapped the ABP-280 filamin gene (FLN) to Xq28 by Southern blot analysis of somatic cell hybrid lines, by fluorescence in situ hybridization, and through identification of portions of the FLN gene within cosmids and YACs mapped to Xq28. The FLN gene is found within a 200-kb region centromeric to the G6PD locus and telomeric to DSX52 and the color vision locus. © 1993 Academic Press. All rights reserved.

引用

页码：496 / 498

页数：3

共 23 条

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