INDUCTION OF EXPERIMENTAL ALLERGIC ARTHRITIS WITH OUTER SURFACE-PROTEINS OF BORRELIA-BURGDORFERI

被引：40

作者：

GONDOLF, KB

MIHATSCH, M

CURSCHELLAS, E

DUNN, JJ

BATSFORD, SR

机构：

[1] INST MED MICROBIOL, DEPT IMMUNOL, D-79104 FREIBURG, GERMANY

[2] KANTONSSPITAL, BASEL, SWITZERLAND

[3] BROOKHAVEN NATL LAB, UPTON, NY USA

来源：

ARTHRITIS AND RHEUMATISM | 1994年 / 37卷 / 07期

关键词：

D O I：

10.1002/art.1780370713

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. The arthritogenic potential of the cationic outer surface proteins Methods. Water-soluble Osps were prepared by butanol extraction and were administered by intraarticular injection. Tissue injury was assessed by scintigraphy and histology. Results. A mild arthritis was seen in naive rats. Preimmunized animals had more severe, longer lasting bouts of inflammation. Conclusion. The Osps of Borrelia burgdorferi are potent arthritogens in rats. These inmunodominant antigens may play a role in the development of Lyme arthritis in humans.

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页码：1070 / 1077

页数：8

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