LEUKOTRIENE-B4 IN THE IMMUNE-SYSTEM

被引：92

作者：

CLAESSON, HE

ODLANDER, B

JAKOBSSON, PJ

机构：

[1] Department of Physiological Chemistry, Karolinska Institutet, Stockholm

来源：

INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY | 1992年 / 14卷 / 03期

关键词：

D O I：

10.1016/0192-0561(92)90174-J

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Leukotriene (LT) B4 is a biologically active molecule derived from arachidonic acid via the 5-lipoxygenase pathway. It mediates certain inflammatory and immunological reactions. The role of LTB4 in the immune system has been questioned since lymphocytes have been regarded to lack the enzymes involved in LTB4 formation. This review focuses on the recently described biosynthesis of LTB4 in B-lymphocytes and the effects of this compound on lymphocyte functions.

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页码：441 / 449

页数：9

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