EFFECTS OF CALCIUM-ANTAGONISTS ON THE ERYTHROCYTE-MEMBRANE

被引：27

作者：

ABE, H ^{[1
]}

KATADA, K ^{[1
]}

ORITA, M ^{[1
]}

NISHIKIBE, M ^{[1
]}

机构：

[1] BANYU PHARMACEUT CO LTD,CENT RES LABS,MEGURO KU,TOKYO 153,JAPAN

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1991年 / 43卷 / 01期

关键词：

D O I：

10.1111/j.2042-7158.1991.tb05441.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of dihydropyridine compounds nimodipine, nicardipine and NB818 (isopropyl methyl-6-carbamoyloxymethyl-4-(2,3-dichlorophenyl)-1,4-dihydro-2-methyl-3,5-pyridine-dicarboxylate) on erythrocyte membranes have been studied. These compounds showed protective effects against hypotonic haemolysis, but not against heat-induced haemolysis. An increase in deformability of erythrocytes by these calcium antagonists was observed using a capillary tube centrifugal method. The erythrocytes showed slight stomatocytosis after 30 min of incubation with calcium antagonists, but did not show significant changes in mean corpuscular volume and ATP levels.

引用

页码：22 / 26

页数：5

共 18 条

[1] TREATMENT OF STABLE ANGINA OF EFFORT WITH VERAPAMIL - A DOUBLE-BLIND, PLACEBO-CONTROLLED RANDOMIZED CROSSOVER STUDY [J].

BRODSKY, SJ ;

CUTLER, SS ;

WEINER, DA ;

MCCABE, CH ;

RYAN, TJ ;

KLEIN, MD .

CIRCULATION, 1982, 66 (03) :569-574

[2]

BROWN JH, 1967, P SOC EXP BIOL MED, V125, P837

[3]

GRYNKIEWICZ G, 1985, J BIOL CHEM, V260, P3440

[4] EFFECTS OF NIFEDIPINE ON MYOCARDIAL PERFUSION AND ISCHEMIC-INJURY IN DOGS [J].

HENRY, PD ;

SHUCHLEIB, R ;

BORDA, LJ ;

ROBERTS, R ;

WILLIAMSON, JR ;

SOBEL, BE .

CIRCULATION RESEARCH, 1978, 43 (03) :372-380

[5] COMPARATIVE PHARMACOLOGY OF CALCIUM ANTAGONISTS - NIFEDIPINE, VERAPAMIL AND DILTIAZEM [J].

HENRY, PD .

AMERICAN JOURNAL OF CARDIOLOGY, 1980, 46 (06) :1047-1058

[6]

IIDA Y, 1989, ACTA HEPATOLOGICA JA, V30, P850

[7]

KAWAI C, 1981, CIRCULATION, V63, P1035, DOI 10.1161/01.CIR.63.5.1035

[8] DEFORMATION OF TRANSFORMING RED-CELLS IN VARIOUS PH SOLUTIONS [J].

NAGASAWA, T .

EXPERIENTIA, 1981, 37 (09) :977-978

[9]

NAGASAWA T, 1980, Osaka City Medical Journal, V26, P1

[10] CARDIOVASCULAR EFFECTS OF NPK-1886, A NEW DIHYDROPYRIDINE COMPOUND WITH CALCIUM ENTRY BLOCKING ACTIVITY [J].

NAGURA, J ;

MURAYAMA, B ;

HARADA, N ;

SUZUKI, K ;

MIYANO, T ;

YAJIMA, M ;

TAKEYA, K .

JAPANESE JOURNAL OF PHARMACOLOGY, 1986, 40 (03) :399-409

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