PROTECTIVE EFFECT OF DEPRENYL AGAINST 1-METHYL-4-PHENYLPYRIDINIUM NEUROTOXICITY IN RAT STRIATUM

被引：31

作者：

VIZUETE, ML ^{[1
]}

STEFFEN, V ^{[1
]}

AYALA, A ^{[1
]}

CANO, J ^{[1
]}

MACHADO, A ^{[1
]}

机构：

[1] UNIV SEVILLE,FAC FARM,DEPT BIOQUIM BROMATOL & TOXICOL,SEVILLE,SPAIN

来源：

NEUROSCIENCE LETTERS | 1993年 / 152卷 / 1-2期

关键词：

STRIATUM; MONOAMINE; DEPRENYL; MPP+; HPLC-ED; SUPEROXIDE DISMUTASE; CATALASE; RAT;

D O I：

10.1016/0304-3940(93)90496-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Rats were treated with deprenyl for 3 weeks. Afterwards, slices of the corpus striatum were incubated with 1-methyl-4-phenylpyridinium ion (MPP+). Concentrations of dopamine and its metabolite concentrations were assayed. The effect of MPP+ in animals treated with deprenyl was smaller than in controls, indicating that deprenyl protects against MPP+. We also measured superoxide dismutase (SOD) and catalase activities and carbonyl group content of the proteins. Both activities increased in deprenyl-treated rats, and the amount of carbonyl groups was unchanged. These results suggest that the protective effect of deprenyl is independent of the monoamine oxidase-B inhibitor and of the induction of SOD and catalase activities.

引用

页码：113 / 116

页数：4

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