EFFICACY OF 4-METHYLPYRAZOLE IN ETHYLENE-GLYCOL POISONING - CLINICAL AND TOXICOKINETIC ASPECTS

被引：37

作者：

HARRY, P

TURCANT, A

BOUACHOUR, G

HOUZE, P

ALQUIER, P

ALLAIN, P

机构：

[1] CTR HOSP,BIOCHIM & PHARMACOL LAB,F-78150 LE CHESNAY,FRANCE

[2] CHU ANGERS,PHARMACOL & TOXICOL LAB,F-49033 ANGERS 01,FRANCE

来源：

HUMAN & EXPERIMENTAL TOXICOLOGY | 1994年 / 13卷 / 01期

关键词：

D O I：

10.1177/096032719401300109

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Potentially fatal ethylene glycol intoxication in an adult with normal renal function was treated with 4-methylpyrazole administered three hours after the incident occurred. The plasma ethylene glycol concentration was 3.5 g l-1 on admission. The metabolic acidosis present on admission resolved within four hours, and the subsequent clinical course was uneventful. The apparent plasma half-life of ethylene glycol was 16 h and the mean renal and plasma clearances of ethylene glycol were 24 and 25 ml min-1, respectively. These results support the hypothesis that complete blockade of hepatic metabolism of ethylene glycol is achieved by 4-methylpyrazole, The only side-effect observed as a result of treatment was a transient slight increase in serum transaminase activity.

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页码：61 / 64

页数：4

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