FOS INDUCTION IN BRAIN-STEM NEURONS BY INTRAVENOUS HYPERTONIC SALINE IN THE CONSCIOUS RAT

被引：29

作者：

HOCHSTENBACH, SL ^{[1
]}

SOLANOFLORES, LP ^{[1
]}

CIRIELLO, J ^{[1
]}

机构：

[1] UNIV WESTERN ONTARIO,HLTH SCI CTR,DEPT PHYSIOL,LONDON N6A 5C1,ONTARIO,CANADA

来源：

NEUROSCIENCE LETTERS | 1993年 / 158卷 / 02期

基金：

英国医学研究理事会;

关键词：

C-FOS; OSMOREGULATION; NUCLEUS OF THE SOLITARY TRACT; VENTROLATERAL MEDULLA; PARABRACHIAL NUCLEUS; CARDIOVASCULAR REGULATION;

D O I：

10.1016/0304-3940(93)90270-U

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Experiments were done in conscious rats to investigate the effect of intravenous infusion of hypertonic saline on the induction of the protein Fos, in brainstem neurons. Neurons containing Fos-like immunoreactivity were observed in the caudal nucleus of the solitary tract (NTS), the caudal and rostral ventrolateral medulla, and parabrachial nucleus after an infusion of solutions containing 1.4 M NaCl. Little or no expression of Fos was detected in brainstem neurons after intravenous infusions of either physiological (143 mM) or hypotonic (106 mM) NaCl solutions. These data provide evidence for the involvement of brainstem structures in osmoregulatory functions and suggest that brainstem neuronal circuits that function in cardiovascular regulation may also be shared by those involved in body fluid homeostasis.

引用

页码：225 / 228

页数：4

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