TRANSLOCATION-(9-22)(Q22-Q12) - A RECURRENT CHROMOSOME ABNORMALITY IN EXTRASKELETAL MYXOID CHONDROSARCOMA

被引：56

作者：

HIRABAYASHI, Y

ISHIDA, T

YOSHIDA, MA

KOJIMA, T

EBIHARA, Y

MACHINAMI, R

IKEUCHI, T

机构：

[1] TOKYO MED & DENT UNIV,MED RES INST,DEPT CYTOGENET,BUNKYO KU,TOKYO 113,JAPAN

[2] UNIV TOKYO,FAC MED,DEPT PATHOL,TOKYO 113,JAPAN

[3] TOKYO MED COLL,DEPT PATHOL 2,TOKYO,JAPAN

来源：

CANCER GENETICS AND CYTOGENETICS | 1995年 / 81卷 / 01期

关键词：

D O I：

10.1016/0165-4608(94)00201-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cytogenetic analysis of a case of extraskeletal myxoid chondrosarcoma revealed a reciprocal translocation between 9q and 22q in almost all metaphases analyzed. Structural rearrangements involving 9q and 22q have been reported previously in three cases of extraskeletal myxoid chondrosarcoma. The breakpoints on chromosomes 9 and 22 in the present case were in regions 9q22-q31 and 22q11-q12.2, respectively. The same breakpoints were present in all three previously reported cases. Thus, this recently identified rearrangement of 9q and 22q may serve as a critical cytogenetic parameter for the diagnosis and classification of extraskeletal myxoid chondrosarcoma, as well as being a primary chromosomal event in the course of development of this rare malignancy

引用

页码：33 / 37

页数：5

共 16 条

[1] CONSTITUTIONAL TRANSLOCATION T(4,22) (Q12,Q12.2) ASSOCIATED WITH NEUROFIBROMATOSIS TYPE-2 [J].