INVOLVEMENT OF THE 4Q21 REGION IN HUMAN-MALIGNANT MELANOMAS - CYTOGENETIC AND IMMUNOCYTOCHEMICAL CHARACTERIZATION OF 3 PRIMARY-CELL CULTURES

被引：6

作者：

GRAMMATICO, P

ROCCELLA, M

CATRICALA, C

ROCCELLA, F

BUCHER, S

MORDENTI, C

AMANTEA, A

DIROSA, C

DELPORTO, G

机构：

[1] OSPED L SPALLAZANI,UNIV LA SAPIENZA,CATTEDRA GENET MED,I-00149 ROME,ITALY

[2] IST DERMATOL S MARIA & S GALLICANO,ROME,ITALY

来源：

WORLD JOURNAL OF SURGERY | 1995年 / 19卷 / 03期

关键词：

D O I：

10.1007/BF00299156

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

The GRO1 oncogene (melanoma growth-stimulating activity alpha) has been localized in region 4q21, The involvement of this chromosomal region in clonal aberrations found in primary melanoma cell cultures could have an important role in the etiology and pathogenesis of this tumor. We characterized three primary cell cultures obtained from different patients, each of which showed clonal chromosomal aberrations involving the 4q21 region.

引用

页码：350 / 351

页数：2