SPINAL C-FOS INDUCTION BY SENSORY STIMULATION IN NEONATAL RATS

被引：66

作者：

WILLIAMS, S ^{[1
]}

EVAN, G ^{[1
]}

HUNT, SP ^{[1
]}

机构：

[1] INT CANC RES FUND LABS,LONDON,ENGLAND

来源：

NEUROSCIENCE LETTERS | 1990年 / 109卷 / 03期

基金：

英国惠康基金;

关键词：

C-fos; Development; Immunocytochemistry; Pain; Rat; Spinal cord;

D O I：

10.1016/0304-3940(90)90013-Y

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

C-fos immunocytochemistry was used to investigate the functional connectivity between primary afferent nociceptive fibres and second-order neurones in the spinal cord of the anaesthetised neonatal rat. Subcutaneous injection of 50 mg/kg capsaicin potently induced c-fos in the spinal cord on the first postnatal day (P1), whilst plantar injection of dilute formalin was much less effective until P3. In contrast with the adult, there was no c-fos response of the neonatal rat spinal cord to cutaneous application of the C-fibre irritant, mustard oil. It is concluded that spinal c-fos expression induced by noxious sensory stimulation can occur before the development of mature functional synaptic contact with first-order neurones. © 1990.

引用

页码：309 / 314

页数：6

共 27 条

[1] NEUROBIOLOGY - 2ND MESSENGER DUALISM IN NEUROMODULATION AND MEMORY [J].