EFFECT OF FOOD AND ACTIVITY ON THE REPRODUCIBILITY OF ISOTOPIC GFR ESTIMATION

被引:26
作者
WILKINSON, J [1 ]
FLEMING, JS [1 ]
WALLER, DG [1 ]
机构
[1] SOUTHAMPTON GEN HOSP,DEPT CLIN PHARMACOL,CLIN PHARMACOL GRP,SOUTHAMPTON SO9 4XY,HANTS,ENGLAND
关键词
D O I
10.1097/00006231-199010000-00005
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
The reproducibility of the plasma clearance of99TcmDTPA was studied in 26 patients under standardized conditions with the subject fasting and at rest. The coefficient of variation of duplicate measurements in patients with glomerular filtration rates (GRF's) ranging from 11- 103 ml min-1was 8%. Mean GFR following a breakfast containing 670 kcal and 31 g protein was increased significantly from 40.7+28.1 ml min-1to 43.6+30.8 ml min-1. When fasted but permitted free exercise there was no consistent trend in GFR but the coefficient of variation of duplicate estimates increased significantly to 12.1%. It is recommended that routine GFR measurement should be carried out fasting or following a light diet with restricted activity. © 1990 Chapman and Hall Ltd.
引用
收藏
页码:697 / 700
页数:4
相关论文
共 12 条
[1]  
Brochner-Mortensen J., Routine methods and their reliability for assessment of glomerular filtration rate in adults, Dan Med Bull, 25, pp. 181-202, (1978)
[2]  
Holland W.W., Whitehead T.P., Value of new laboratory tests in diagnosis and treatment, Lancet, 2, pp. 391-394, (1974)
[3]  
Waller D.G., Keast C.M., Fleming J.S., Ackery D.M., Measurement of glomerular filtration rate with<sup>99</sup>Tc<sup>m</sup>DTPA: Comparison of plasma clearance techniques, J Nucl Med, 28, pp. 372-377, (1987)
[4]  
Brochner-Mortensen J., Rodbro P., Selection of routine method for determination of glomerular filtration rate in adults, Scand J Clin Lab Invest, 36, pp. 35-43, (1976)
[5]  
Bosch J.P., Saccaggi A., Laver A., Ronco C., Belledonne M., Glabman S., Short term protein loading in assessment of patients with renal disease, Am J Med, 75, pp. 943-950, (1983)
[6]  
Levine M.M., Kirschenbaum M.A., Chaudhari A., Wong M.W., Bricker N., Effect of protein on GFR and prostanoid synthesis in normal and uraemic rats, Am J Physiol, 215, pp. F635-FF41, (1986)
[7]  
Jones M.G., Lee K., Swaminathan R., The effect of dietary protein on GFR in normal subjects, Clin Nephrol, 27, pp. 71-75, (1987)
[8]  
Shannon J.A., Jollife N., Smith H.W., The excretion of urine in the dog, the effect of maintenance diet, feeding etc. Upon the quantity of glomerular filtrate, J Clin Invest, 14, pp. 393-401, (1935)
[9]  
Merrill A., Cargill W., The effect of exercise on the renal plasma flow and filtration rate of normal and cardiac subjects, J Clin Invest, 27, pp. 272-277, (1948)
[10]  
Aas K., Blegen E., The renal blood flow and the glomerular filtration rate in congestive heart failure and some other clinical conditions. The effect of exercise and hypoxaemia. A preliminary report, Scand J Clin Lab Invest, 1, pp. 22-32, (1949)