THE EFFECT OF TOPICAL CYCLOSPORINE-A ON THE RABBIT CORNEA - A CLINICAL AND ELECTRON-MICROSCOPIC STUDY

被引：19

作者：

BEHRENSBAUMANN, W ^{[1
]}

THEURING, S ^{[1
]}

BREWITT, H ^{[1
]}

机构：

[1] UNIV HANOVER, D-3000 Hannover, GERMANY

来源：

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY | 1986年 / 224卷 / 06期

关键词：

D O I：

10.1007/BF02154739

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

To investigate the effect of topical cyclosporin A (CSA) on the rabbit cornea, both eyes of 80 animals were treated with CSA 2% eye drops over a 3-week period under various conditions. CSA was dissolved in castor oil or ethanol 13.8 vol. %. Slit-lamp, scanning and transmission electron microscopic examinations were performed. CSA 2% in castor oil given 5 times daily showed no damage to either the corneal epithelium or endothelium. In contrast the solutions containing ethanol revealed considerable epithelial cell damage.

引用

页码：520 / 524

页数：5

共 19 条

[1]

AHONEN J, 1984, CYCLOSPORINE BIOL AC, P876

[2] CICLOSPORIN CONCENTRATION IN THE RABBIT AQUEOUS-HUMOR AND CORNEA FOLLOWING SUBCONJUNCTIVAL ADMINISTRATION - IMPORTANCE OF ANATOMICAL SITE OF INJECTION [J].