EIMERIA-VERMIFORMIS - DIFFERENCES IN THE COURSE OF PRIMARY INFECTION CAN BE CORRELATED WITH LYMPHOCYTE RESPONSIVENESS IN THE BALB/C AND C57BL/6 MOUSE, MUS-MUSCULUS

被引：32

作者：

ROSE, ME ^{[1
]}

WAKELIN, D ^{[1
]}

HESKETH, P ^{[1
]}

机构：

[1] UNIV NOTTINGHAM,DEPT ZOOL,NOTTINGHAM NG7 2RD,ENGLAND

来源：

EXPERIMENTAL PARASITOLOGY | 1990年 / 71卷 / 03期

基金：

英国惠康基金;

关键词：

Adoptive transfer; BALB/c; C57BL/6; Coccidia; Coccidiosis; Eimeria vermiformis; Protozoa; Immunity; Mouse; Proliferative responses; Serum antibody;

D O I：

10.1016/0014-4894(90)90032-8

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

BALB/c and C57BL/6 mice are high- and low-responders, respectively, to infection with Eimeria vermiformis, this genetically determined difference being immunologically mediated. In order to identify the level at which response phenotype is determined, the proliferation of mesenteric lymph node cells and their ability to transfer immunity adoptively were investigated in each strain; the development of circulating serum antibodies to E. vermiformis was also determined. In all respects BALB/c mice responded earlier than the C57BL/ 6 but peak values were similar in both strains. The relationship between the temporal differences noted and the characteristic, differing course of the primary infection in the two strains is discussed. © 1990.

引用

页码：276 / 283

页数：8

共 21 条

[1] MAJOR HISTOCOMPATIBILITY COMPLEX CONTROL OF IMMUNITY ELICITED BY GENETICALLY ENGINEERED EIMERIA-TENELLA (APICOMPLEXA) ANTIGEN IN CHICKENS [J].