STRUCTURAL ANALOGS OF THE ANTIBIOTIC MOENOMYCIN-A WITH A D-GLUCOSE-DERIVED UNIT-F

被引：18

作者：

HEUER, M

HOHGARDT, K

HEINEMANN, F

KUHNE, H

DIETRICH, W

GRZELAK, D

MULLER, D

WELZEL, P

MARKUS, A

VANHEIJENOORT, Y

VANHEIJENOORT, J

机构：

[1] RUHR UNIV,FAK CHEM,D-44780 BOCHUM,GERMANY

[2] HOECHST AG,D-65926 FRANKFURT,GERMANY

[3] UNIV PARIS 11,ORSAY,FRANCE

来源：

TETRAHEDRON | 1994年 / 50卷 / 07期

关键词：

D O I：

10.1016/S0040-4020(01)85066-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Disaccharide derivative 1a is the smallest transglycosylase inhibiting compound known up to now. Structurally closely related compounds 11b and 19c have been synthesized. They do not inhibit the transglycosylase demonstrating the high specificity of the interaction between inhibitor 1a and the binding-site at the enzyme.

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页码：2029 / 2046

页数：18

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