A NEW SYNTHESIS OF UNSYMMETRICAL DIPHENIC ACID-DERIVATIVES - TEMPLATE-DIRECTED INTRAMOLECULAR ULLMANN COUPLING REACTION

被引：21

作者：

TAKAHASHI, M ^{[1
]}

KURODA, T ^{[1
]}

OGIKU, T ^{[1
]}

OHMIZU, H ^{[1
]}

KONDO, K ^{[1
]}

IWASAKI, T ^{[1
]}

机构：

[1] TANABE SEIYAKU CO LTD,DEPT SYNTHET CHEM,APPL BIOCHEM RES LAB,3-16-89 KASHIMA,YODOGAWA KU,OSAKA 532,JAPAN

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 47期

关键词：

UNSYMMETRICAL DIPHENIC ACIDS; INTRAMOLECULAR ULLMANN COUPLING REACTION; SALICYL ALCOHOL; TEMPLATE;

D O I：

10.1016/0040-4039(91)80444-B

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Intramolecular Ullmann coupling reaction of the diesters (6,9), which were prepared by regioselective acylation of salicyl alcohol by using the two different substituted 2-iodobenzoyl chlorides, afforded the unsymmetrical diphenic acid derivatives (7, 10). Hydrogenolysis of the Ullmann coupling product (7) afforded the monoester (12) in an excellent yield.

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页码：6919 / 6922

页数：4

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