2-YEAR FOLLOW-UP-STUDY OF A PATIENT WITH PARKINSONS-DISEASE AND SEVERE MOTOR FLUCTUATIONS TREATED BY COGRAFTS OF ADRENAL-MEDULLA AND PERIPHERAL-NERVE INTO BILATERAL CAUDATE NUCLEI - CASE-REPORT

被引：31

作者：

DATE, I

ASARI, S

OHMOTO, T

机构：

[1] Department of Neurological Surgery, Okayama University Medical School, Okayama, JPN

来源：

NEUROSURGERY | 1995年 / 37卷 / 03期

关键词：

ADRENAL MEDULLA; CO-GRAFT; NEURAL TRANSPLANTATION; PARKINSONS DISEASE;

D O I：

10.1227/00006123-199509000-00022

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

WE PERFORMED CO-GRAFTS of adrenal medulla and peripheral nerve into the bilateral caudate nuclei of a 43-year-old patient with advanced Parkinson's disease who showed severe daily motor fluctuations before surgery. There were no postoperative complications, and a 2-year follow-up result is presented. The patient showed a gradual and significant amelioration of the parkinsonian symptoms starting 2 weeks after transplantation. The alleviation of akinesia during ''off'' periods was the most apparent clinical improvement and continued for 2 years after surgery. The dosage of L-dopa/benserazide was significantly reduced after surgery compared with that before surgery. The results indicate that co-grafts of adrenal medulla with peripheral nerve may be useful for the treatment of Parkinson's disease in the long term.

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页码：515 / 518

页数：4

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