ENZYME-ENZYME INTERACTIONS AND CONTROL ANALYSIS .2. THE CASE OF NONINDEPENDENCE - HETEROLOGOUS ASSOCIATIONS

被引：78

作者：

SAURO, HM

KACSER, H

机构：

[1] Department of Genetics, University of Edinburgh

来源：

EUROPEAN JOURNAL OF BIOCHEMISTRY | 1990年 / 187卷 / 03期

关键词：

D O I：

10.1111/j.1432-1033.1990.tb15330.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The association of different enzymes into a complex may induce changes in the kinetic parameters of its component enzymes. This implies that they cannot be treated as independent catalysts. It will affect the formulations and theorems of control analysis and necessitates the introduction of additional elasticities reflecting the effect of one enzyme on the rate of another. We show how this is achieved as an extension of the classical treatment. We present modified summation and connectivity theorems incorporating both homologous and heterologous interactions. The case of channelling of metabolites in such complexes is considered and an experimental method for its detection is suggested. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：493 / 500

页数：8

共 19 条

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