SIGMA-RECEPTORS MODULATE THE HYPOTHALAMIC-PITUITARY-ADRENAL (HPA) AXIS CENTRALLY - EVIDENCE FOR A FUNCTIONAL INTERACTION WITH NMDA RECEPTORS, INVIVO

被引：67

作者：

IYENGAR, S

MICK, S

DILWORTH, V

MICHEL, J

RAO, TS

FARAH, JM

WOOD, PL

机构：

[1] CNS Diseases Research, G. D. Searle and Company, Monsanto Co., St. Louis, MO 63198

来源：

NEUROPHARMACOLOGY | 1990年 / 29卷 / 03期

关键词：

ACTH; HPA axis; NMDA receptors; sigma receptors;

D O I：

10.1016/0028-3908(90)90017-L

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The present report investigates the modulation of the hypothalamic-pituitary-adrenal (HPA) axis in the rat by sigma receptors, using a selective ligand, (+) pentazocine, and comparing the effects with (+) SKF 10,047. Both compounds stimulate ACTH release potently after central and peripheral administration. These effects are centrally mediated, since they did not release ACTH from anterior pituitary primary cultures. The effects are not blocked by naloxone, but are blocked by the NMDA antagonist, CPP, indicating a centrally mediated functional interaction between NMDA and sigma receptors, in vivo. © 1990.

引用

页码：299 / 303

页数：5

共 8 条

[1]

[Anonymous], 1971, STAT PRINCIPLES EXPT

[2] SYNTHESIS AND EVALUATION OF OPTICALLY PURE [H-3] (+)-PENTAZOCINE, A HIGHLY POTENT AND SELECTIVE RADIOLIGAND FOR SIGMA-RECEPTORS [J].