SIMULTANEOUS DETERMINATION OF CHLOROQUINE AND ITS 3 METABOLITES IN HUMAN PLASMA, WHOLE-BLOOD AND URINE BY ION-PAIR HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：14

作者：

HOUZE, P ^{[1
]}

DEREYNIES, A ^{[1
]}

BAUD, FJ ^{[1
]}

BENATAR, MF ^{[1
]}

PAYS, M ^{[1
]}

机构：

[1] HOP FERNAND WIDAL, F-75475 PARIS 10, FRANCE

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1992年 / 574卷 / 02期

关键词：

D O I：

10.1016/0378-4347(92)80044-Q

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A method was developed for the separation and measurement of chloroquine and three metabolites (desethylchloroquine, bisdesethylchloroquine and 4-amino-7-chloroquinoline) in biological samples by ion-pair high-performance liquid chromatography with UV detection. The method uses 2,3-diaminonaphthalene as an internal standard and provides a limit of detection between 1 and 2 ng/ml for chloroquine and its metabolites. The assay was linear in the range 12.5-250 ng/ml and the analytical recovery and reproducibility were sufficient. The assay was applied to the analysis of biological samples from a patient undergoing chloroquine chemoprophylaxis and a patient who had ingested chloroquine in a suicide attempt.

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收藏

页码：305 / 312

页数：8

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