EPSTEIN-BARR-VIRUS AS A TRIGGER FOR AUTOIMMUNE HEPATITIS IN SUSCEPTIBLE INDIVIDUALS

被引：149

作者：

VENTO, S ^{[1
]}

GUELLA, L ^{[1
]}

MIRANDOLA, F ^{[1
]}

CAINELLI, F ^{[1
]}

DIPERRI, G ^{[1
]}

SOLBIATI, M ^{[1
]}

FERRARO, T ^{[1
]}

CONCIA, E ^{[1
]}

机构：

[1] A PUGLIESE HOSP,INFECT DIS UNIT,CATANZARO,ITALY

来源：

LANCET | 1995年 / 346卷 / 8975期

关键词：

D O I：

10.1016/S0140-6736(95)91438-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

During follow-up of healthy relatives of 13 patients with autoimmune hepatitis, seven cases of infectious mononucleosis due to Epstein-Barr virus (EBV) occurred. In two of these seven, before EBV infection, there was a defect in suppressor-inducer T lymphocytes specifically controlling immune responses to the asialoglycoprotein receptor, an antigen expressed on the hepatocyte surface. In these two, antibodies to this autoantigen persisted and increased after infectious mononucleosis, and autoimmune hepatitis developed within 4 months. In susceptible individuals, EBV is a trigger for autoimmune hepatitis.

引用

页码：608 / 609

页数：2

共 10 条

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