CATALYTIC ENANTIOSELECTIVE MACROLIDE SYNTHESIS .2. USE OF DIFFERENTIAL DEPROTECTION PROTOCOLS

被引:24
作者
JONES, GB
CHAPMAN, BJ
HUBER, RS
BEATY, R
机构
[1] Department of Chemistry, Clemson University, Clemson
关键词
D O I
10.1016/0957-4166(94)80156-8
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
Catalytic enantioselective synthesis of Phorcantholide I has been achieved. Key stereochemistry was introduced using a chiral arene chromium tricarbonyl based catalyst to mediate the addition of dimethyl zinc to a functionalised aldehyde. During the synthesis, a method for the Selective deprotection of the trityloxy group was revealed and developed.
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页码:1199 / 1202
页数:4
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