FEASIBILITY STUDIES ON RADIATION STERILIZATION OF CEPHRADINE

被引：4

作者：

ABUIRJEIE, MA

ABDELAZIZ, AA

ABDELHAMID, ME

机构：

[1] Faculty of Pharmacy, Jordan University of Science and Technology, Irbid

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1990年 / 16卷 / 10期

关键词：

D O I：

10.3109/03639049009025778

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A comprehensive study was carried out to examine and evaluate the feasibility of radiation sterilization of cephradine antibiotic in the solid dry state. Absorbed gamma ray doses in the range of 5-25 kGy caused a dose-dependent loss of bactericidal activity. Moreover, radiation caused a dose-dependent degradation of the antibiotic and decrease in cephradine content due to radiation conversion to cephalexin. The former deleterious effect was detected spectrophotometrically and confirmed by high-performance liquid chromatography (HPLC). The latter effect was detected by NMR spectroscopy and by HPLC. The study revealed a noticeable change in the tint of the irradiated powdered drug which is dose-dependent and clearly remarkable at high radiation doses. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：1661 / 1673

页数：13