A NEW SYNTHESIS OF THE CORTICOSTEROID SIDE-CHAIN

被引：20

作者：

CIATTINI, PG

MORERA, E

ORTAR, G

机构：

[1] UNIV ROMA LA SAPIENZA,DIPARTIMENTO STUDI FARMACEUT,I-00185 ROME,ITALY

[2] UNIV ROMA LA SAPIENZA,CNR,CTR STUDIO CHIM FARM,I-00185 ROME,ITALY

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 13期

关键词：

D O I：

10.1016/S0040-4039(00)98812-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A short and efficient approach to 3β-acetoxy-21-hydroxypregna-5,16-dien-20-one (6b) has been accomplished using the palladium-catalyzed coupling reaction of 17-enol triflate3 with α-buthoxyethenyl zinc chloride (8), followed by oxidation of the resultant unsaturated enol ether4a withm-chloroperbenzoic acid in the presence of potassium acetate. © 1990 Pergamon Press plc.

引用

页码：1889 / 1892

页数：4

共 24 条

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[7] DANIEWSKI AR, 1984, SYNTHESIS-STUTTGART, P132
[8] PALLADIUM CATALYSIS IN CEPHALOSPORIN CHEMISTRY - A VERSATILE NEW APPROACH TO 3-SUBSTITUTED CEPHEMS
FARINA, V
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[J]. TETRAHEDRON LETTERS, 1988, 29 (47) : 6043 - 6046
[9] FIESER LF, 1959, STEROIDS
[10] A NOVEL-APPROACH TO CARDENOLIDES
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ORTAR, G
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1985, 50 (11) : 1990 - 1992

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