THE ROLES OF MACROPHAGE (M-PHI) AND PGE-2 IN POSTBURN IMMUNOSUPPRESSION

被引：20

作者：

LIU, Y ^{[1
]}

HSU, BX ^{[1
]}

机构：

[1] JINAN UNIV,COLL MED,DEPT MICROBIOL & IMMUNOL,CANTON 510632,PEOPLES R CHINA

来源：

BURNS | 1992年 / 18卷 / 02期

关键词：

D O I：

10.1016/0305-4179(92)90010-R

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Postburn immunosuppression in mice with full skin thickness burns was assessed after Con A stimulation of splenic lymphocytes. The immunosuppression was detected within 24 h of injury and was maximal 3-7 days later. Such lymphocyte proliferation was enhanced by depletion of adherent cells (M-PHI) in burned mice and could be depressed in normal mice by injection of these adherent cells from burned mice. These results suggest the presence of M-PHI with a suppressor function. No difference in spontaneous blastogenic transformation (SBT) of spleen cells between the burned and normal mice was found, but after removal of the M-PHI-s the SBT of spleen cells of burned mice became significantly elevated. Hence both M-PHI and lymphocytes in mouse spleen cells were activated after severe thermal injury.

引用

页码：132 / 136

页数：5

共 21 条

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