INVITRO DISSOLUTION PROFILE OF THEOPHYLLINE LOADED ETHYL CELLULOSE MICROSPHERES PREPARED BY EMULSIFICATION SOLVENT EVAPORATION

被引：11

作者：

DAS, SK ^{[1
]}

机构：

[1] JADAVPUR UNIV,DEPT PHARMACEUT TECHNOL,CALCUTTA 700032,W BENGAL,INDIA

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1991年 / 17卷 / 18期

关键词：

D O I：

10.3109/03639049109048091

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Theophylline was entrapped in ethyl cellulose microspheres by a water/oil/water emulsification-solvent evaporation method. Aqueous solution of drug was emulsified into a solution of ethyl cellulose in toluene, containing polyisobutylene as protective colloid, followed by emulsification of this primary emulsion into an external aqueous phase to form a water/oil/water emulsion. Microspheres was formed after solvent evaporation and precipitation of ethyl cellulose. In vitro dissolution profile and effect of polyisobutylene on it were studied.

引用

页码：2521 / 2528

页数：8

共 13 条

[1] MONODISPERSE POLYMERIC SPHERES IN THE MICRON SIZE RANGE BY A SINGLE STEP PROCESS [J].

ALMOG, Y ;

REICH, S ;

LEVY, M .

BRITISH POLYMER JOURNAL, 1982, 14 (04) :131-136

[2]

BAYER E, 1988, NOV INT S CHROM REH, P53

[3]

BECK LR, 1979, FERTIL STERIL, V31, P545

[4] EVALUATION OF TOXIC SERUM THEOPHYLLINE CONCENTRATIONS [J].

BURKLE, WS ;

GWIZDALA, CJ .

AMERICAN JOURNAL OF HOSPITAL PHARMACY, 1981, 38 (08) :1164-1166

[5] POLYMER LATTICES AS MODEL COLLOIDS [J].

HEARN, J ;

WILKINSON, MC ;

GOODALL, AR .

ADVANCES IN COLLOID AND INTERFACE SCIENCE, 1981, 14 (2-3) :173-236

[6]

HENDELES L, 1983, PHARMACOTHERAPY, V3, P2

[7] PHARMACOKINETICS AND RELATIVE BIOAVAILABILITY OF ORAL THEOPHYLLINE CAPSULES [J].

LESKO, LJ ;

CANADA, AT ;

EASTWOOD, G ;

WALKER, D ;

BROUSSEAU, DR .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1979, 68 (11) :1392-1394

[8] ACROLEIN POLYMERIZATION - MONODISPERSE, HOMO, AND HYBRIDO MICROSPHERES, SYNTHESIS, MECHANISM, AND REACTIONS [J].

MARGEL, S ;

WIESEL, E .

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 1984, 22 (01) :145-158

[9] DOSE-DEPENDENT KINETICS OF THEOPHYLLINE IN ADULTS WITH PULMONARY-DISEASES [J].

MASSEY, KL ;

GOTZ, VP ;

RUSSELL, WL .

THERAPEUTIC DRUG MONITORING, 1984, 6 (03) :284-289

[10] UNIFORM POLYMER PARTICLES BY DISPERSION POLYMERIZATION IN ALCOHOL [J].

TSENG, CM ;

LU, YY ;

ELAASSER, MS ;

VANDERHOFF, JW .

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 1986, 24 (11) :2995-3007

← 1 2 →