VINCRISTINE IN STEROID-RESISTANT NEPHROTIC SYNDROME

被引：11

作者：

ALMEIDA, MP

ALMEIDA, HA

ROSA, FC

机构：

[1] Nephrology Unit, Department of Paediatrics, University of Lisbon

来源：

PEDIATRIC NEPHROLOGY | 1994年 / 8卷 / 01期

关键词：

NEPHROTIC SYNDROME; FOCAL AND SEGMENTAL GLOMERULOSCLEROSIS; STEROID-RESISTANT; VINCRISTINE;

D O I：

10.1007/BF00868273

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The therapeutic response to vincristine was examined in seven children (aged 2-15 years) with corticosteroid-resistant (CR) nephrotic syndrome (NS) with focal and segmental glomerulosclerosis (FGS). Five were also resistant to cyclophosphamide. Vincristine was given weekly (1.5 mg/m(2) intravenously) for 8 weeks. Simultaneously, prednisone (60 mg/m(2) per day, orally) was given for 4 weeks and then gradually tapered. Two of these patients had a complete and stable remission; in five no benefit was observed. It was not possible to identify any characteristics to predict the response to vincristine. Although there is a case for trying vincristine therapy in CR NS with FGS, the results of this study are not encouraging and a better understanding of its action and indications is necessary.

引用

页码：79 / 80

页数：2

共 11 条

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