DELAYED-ONSET OF ALZHEIMERS-DISEASE WITH NONSTEROIDAL ANTIINFLAMMATORY AND HISTAMINE-H2 BLOCKING-DRUGS

被引：383

作者：

BREITNER, JCS ^{[1
]}

WELSH, KA ^{[1
]}

HELMS, MJ ^{[1
]}

GASKELL, PC ^{[1
]}

GAU, BA ^{[1
]}

ROSES, AD ^{[1
]}

PERICAKVANCE, MA ^{[1
]}

SAUNDERS, AM ^{[1
]}

机构：

[1] DUKE UNIV, MED CTR, JOSEPH & KATHLEEN BRYAN ALZHEIMERS DIS RES CTR, DURHAM, NC 27710 USA

来源：

NEUROBIOLOGY OF AGING | 1995年 / 16卷 / 04期

基金：

美国国家卫生研究院;

关键词：

ALZHEIMERS DISEASE; ONSET; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; HISTAMINE H2 BLOCKING DRUGS; INFLAMMATION; CYCLOOXYGENASE; HISTAMINE; EXCITOTOXICITY; NMDA GLUTAMATE RECEPTORS;

D O I：

10.1016/0197-4580(95)00049-K

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 [法学]; 0303 [社会学]; 100203 [老年医学];

摘要：

Factors that modify onset of Alzheimer's disease (AD) may be revealed by comparing environmental exposures in affected and unaffected members of discordant twin pairs or sibships. Among siblings at high risk of AD, sustained use of nonsteroidal anti-inflammatory drugs (NSAIDs) was associated with delayed onset and reduced risk of AD. After adjustment for use of NSAIDs, there was minimal effect on onset with reported history of any of three common illnesses (arthritis, diabetes, or acid-peptic disease). However, independent of exposure to NSAIDs, onset was unexpectedly delayed in those reporting extended use of histamine H2 blocking drugs. Randomized clinical trials will be needed to affirm the utility of these drugs for prevention, but the present findings may have implications for pathogenesis: because NSAIDs block the calcium-dependent postsynaptic cascade that induces excitotoxic cell death in NMDA-reactive neurons, and because histamine potentiates such events, excitotoxicity may deserve additional investigation in AD.

引用

页码：523 / 530

页数：8

共 42 条

[1]

ENHANCEMENT BY HISTAMINE OF NMDA-MEDIATED SYNAPTIC TRANSMISSION IN THE HIPPOCAMPUS [J].