A COMBINED MAGNETIC SECTOR-TIME-OF-FLIGHT MASS-SPECTROMETER FOR STRUCTURAL DETERMINATION STUDIES BY TANDEM MASS-SPECTROMETRY

被引：83

作者：

BATEMAN, RH ^{[1
]}

GREEN, MR ^{[1
]}

SCOTT, G ^{[1
]}

CLAYTON, E ^{[1
]}

机构：

[1] ZENECA PHARMACEUT,MACCLESFIELD,CHESHIRE,ENGLAND

来源：

RAPID COMMUNICATIONS IN MASS SPECTROMETRY | 1995年 / 9卷 / 13期

关键词：

D O I：

10.1002/rcm.1290091302

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A combined magnetic sector-time-of-flight instrument has been constructed and used with both continuous (liquid secondary ion mass spectrometry and electrospray ionization) and pulsed (matrix-assisted laser desorption/ionization) ion sources. The design includes provision for both low- and high-energy gas collision induced decompositions and orthogonal acceleration of the product ions into the time-of-flight mass analyser. Tandem mass spectra may be acquired for singly and multiply charged precursor ions and reliable mass measurements are easily obtained. Product-ion mass spectra are quite reproducible regardless of any instability in the precursor ion beam intensity.

引用

页码：1227 / 1233

页数：7

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