MUTANTS OF PURINE METABOLISM IN CULTURED MOUSE AND HAMSTER CELLS

被引：16

作者：

ASTRIN, KH

CASKEY, CT

机构：

[1] BAYLOR UNIV, COLL MED,ROBERT J KLEBERG JR,CTR HUMAN GENET, DEPT MED, HOUSTON, TX 77030 USA

[2] BAYLOR UNIV, COLL MED, ROBERT J KLEBERG JR CTR HUMAN GENET, DEPT BIOCHEM, HOUSTON, TX 77030 USA

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 1976年 / 176卷 / 02期

关键词：

D O I：

10.1016/0003-9861(76)90182-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The regulation of purine metabolism in mammalian cells is poorly understood presently. A variety of mutants in hamster and mouse is now available for these studies. Selective methods provide the potential for isolation of a greater variety and number of such mutants. The methods are now available for extensive study of the purine biosynthetic pathway with respect to both its genetic organization and cellular regulation. These mouse and hamster mutants may facilitate understanding of this multistep pathway which until recently was limited to the study of rare human mutants.

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页码：397 / 410

页数：14

相关论文

共 119 条

[1] PURINE NUCLEOSIDE METABOLISM IN ERYTHROCYTES OF PATIENTS WITH ADENOSINE-DEAMINASE DEFICIENCY AND SEVERE COMBINED IMMUNODEFICIENCY [J].

AGARWAL, RP ;

CRABTREE, GW ;

PARKS, RE ;

NELSON, JA ;

KEIGHTLEY, R ;

PARKMAN, R ;

ROSEN, FS ;

STERN, RC ;

POLMAR, SH .

JOURNAL OF CLINICAL INVESTIGATION, 1976, 57 (04) :1025-1035

[2] HAMSTER ALPHA-AMANITINE-RESISTANT RNA POLYMERASE-II ABLE TO TRANSCRIBE POLYOMA-VIRUS GENOME IN SOMATIC-CELL HYBRIDS [J].

AMATI, P ;

BLASI, F ;

DIPORZIO, U ;

RICCIO, A ;

TRABONI, C .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1975, 72 (02) :753-757

[3]

ATKINS JH, 1968, GENETICS, V60, P781

[4]

BALIS ME, 1968, ANTAGONISTS NUCLEIC, P5

[5]

Basilico C, 1974, Methods Cell Biol, V8, P1, DOI 10.1016/S0091-679X(08)60440-9

[6] MUTATIONS AFFECTING STRUCTURE OF HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE IN CULTURED CHINESE-HAMSTER CELLS [J].

BEAUDET, AL ;

ROUFA, DJ ;

CASKEY, CT .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1973, 70 (02) :320-324

[7] GOUT WITH PURINE OVERPRODUCTION DUE TO INCREASED PHOSPHORIBOSYLPYROPHOSPHATE SYNTHETASE-ACTIVITY [J].

BECKER, MA ;

MEYER, LJ ;

SEEGMILL.JE .

AMERICAN JOURNAL OF MEDICINE, 1973, 55 (02) :232-242

[8] PATTERNS OF PHOSPHORIBOSYLPYROPHOSPHATE AND RIBOSE-5-PHOSPHATE CONCENTRATION AND GENERATION IN FIBROBLASTS FROM PATIENTS WITH GOUT AND PURINE OVERPRODUCTION [J].

BECKER, MA .

JOURNAL OF CLINICAL INVESTIGATION, 1976, 57 (02) :308-318

[9] GENETIC ASPECTS OF GOUT [J].

BECKER, MA ;

SEEGMILLER, JE .

ANNUAL REVIEW OF MEDICINE, 1974, 25 :15-28

[10] HUMAN PHOSPHORIBOSYLPYROPHOSPHATE SYNTHETASE - INCREASED ENZYME SPECIFIC ACTIVITY IN A FAMILY WITH GOUT AND EXCESSIVE PURINE SYNTHESIS [J].

BECKER, MA ;

KOSTEL, PJ ;

MEYER, LJ ;

SEEGMILLER, JE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1973, 70 (10) :2749-2752

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