THE COMPACTION PROPERTIES OF POLYETHYLENE GLYCOLS

被引:21
作者
ALANGARI, AA
KENNERLEY, JW
NEWTON, JM
机构
[1] UNIV LONDON, SCH PHARM, 29-39 BRUNSWICK SQ, LONDON WC1N 1AX, ENGLAND
[2] UNIV NOTTINGHAM, DEPT PHARM, NOTTINGHAM NG7 2RD, ENGLAND
关键词
D O I
10.1111/j.2042-7158.1985.tb05030.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The mechanical properties of polyethylene glycol (PEG) powders of different average MW have been characterized in terms of their yield pressure, determined from the densification of compacts by the method of Heckel. The yield pressure was found to be proportional to the MW of the PEG. The densification which occurred during compaction was greater the lower the MW. In terms of compact tensile strength. PEG 10,000 produced the greatest strength for a given pressure. This arises from its ability to deform plastically to form a compact and be of sufficient intrinsic strength to resist fracture during the diametral compression test. Higher MW PEG do not allow sufficient plastic flow during consolidation for their inherent higher strength to be used.
引用
收藏
页码:151 / 153
页数:3
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