N-(1-BENZOTRIAZOL-1-YLALKYL)AMIDES, VERSATILE ALPHA-AMIDOALKYLATION REAGENTS .1. ALPHA-AMIDOALKYLATION OF CH ACIDS

被引：69

作者：

KATRITZKY, AR

PERNAK, J

FAN, WQ

SACZEWSKI, F

机构：

[1] Department of Chemistry, University of Florida, Gainesville

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1991年 / 56卷 / 14期

关键词：

D O I：

10.1021/jo00014a020

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-(1-Benzotriazol-1-ylalkyl)amides 2, easily prepared from an amide and an aldehyde with benzotriazole, react smoothly with CH acids under mild conditions to give the alpha-amidoalkylation products in good yields. Benzotriazole aminals also react with CH acids in the presence of methyl iodide.

引用

页码：4439 / 4443

页数：5

共 44 条

[1]

BALON YG, 1981, ZH ORG KHIM+, V17, P442

[2] NEW SYNTHESIS OF N-ACYL AROMATIC ALPHA-AMINO-ACIDS - AMIDOALKYLATION OF AROMATIC-COMPOUNDS WITH GLYOXYLIC-ACID DERIVATIVES [J].